The Knicks and Clippers were tied at 50 at halftime, but New York was outscored by 14 points as they lost their third straight game 109-95.
JR Smith played 34 minutes off the bench and scored 24 points.
Tyson Chandler and Andrea Bargnani combined for 25 points and 20 rebounds. Raymond Felton had 9 assists, but only 5 points. Iman Shumpert was scoreless in 24 minutes.
For the Clippers, Blake Griffin had 32 points and 7 boards. DeAndre Jordan had 11 points and 16 rebounds. Former Knick Jamal Crawford came off the bench to score 29 points in 28 minutes.